Given the adoption and success of modern GUIs across a broad range of software, you'd think that making the case for one would be redundant. However, for some reason Computational Fluid Dynamics (CFD) was a late adopter of GUIs, and for what is predominantly a visual set of disciplines - think geometry, mesh, solver feedback, 3D visualization, and 2D plots. This late adoption is still evident in CFD software today.
Modern CFD GUI: Caedium Professional